RNPEP

RNPEP
Identifiers
Aliases	RNPEP, AP-B, arginyl aminopeptidase, APB
External IDs	OMIM: 602675; MGI: 2384902; HomoloGene: 10628; GeneCards: RNPEP; OMA:RNPEP - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,006,147 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	135,211,822 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; duodenum; ; granulocyte; ; rectum; ; monocyte; ; gonad; ; right uterine tube; ; mucosa of esophagus; ; olfactory zone of nasal mucosa; ; stromal cell of endometrium;
	Top expressed in
	granulocyte; ; seminal vesicula; ; crypt of lieberkuhn of small intestine; ; epithelium of stomach; ; jejunum; ; duodenum; ; pyloric antrum; ; molar; ; right kidney; ; genital tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide binding; zinc ion binding; peptidase activity; aminopeptidase activity; metalloexopeptidase activity; metalloaminopeptidase activity; metallopeptidase activity; hydrolase activity; metal ion binding; epoxide hydrolase activity;
Cellular component	plasma membrane; extracellular exosome; secretory granule; extracellular space; extracellular region;
Biological process	proteolysis; negative regulation of blood pressure; peptide catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6051
	215615
	ENSG00000176393
	ENSMUSG00000041926
	Q9H4A4
	Q8VCT3
	NM_020216; NM_001319182; NM_001319183; NM_001319184
	NM_001159624; NM_145417
	NP_001306111; NP_001306112; NP_001306113; NP_064601
	NP_001153096; NP_663392
	Wikidata
View/Edit Human	View/Edit Mouse

Aminopeptidase B is an enzyme that in humans is encoded by the RNPEP gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176393 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041926 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aurich-Costa J, Cadel S, Gouzy C, Foulon T, Cherif D, Cohen P (Apr 1998). "Assignment of the aminopeptidase B gene (RNPEP) to human chromosome 1 band q32 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 143–4. doi:10.1159/000134703. PMID 9533033.
^ Foulon T, Cadel S, Cohen P (Oct 1999). "Aminopeptidase B (EC 3.4.11.6)". Int J Biochem Cell Biol. 31 (7): 747–50. doi:10.1016/S1357-2725(99)00021-7. PMID 10467730.
^ "Entrez Gene: RNPEP arginyl aminopeptidase (aminopeptidase B)".

External links

The MEROPS online database for peptidases and their inhibitors: M01.014

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

Template:PBB Controls

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176393 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041926 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9533033-5] Aurich-Costa J, Cadel S, Gouzy C, Foulon T, Cherif D, Cohen P (Apr 1998). "Assignment of the aminopeptidase B gene (RNPEP) to human chromosome 1 band q32 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 143–4. doi:10.1159/000134703. PMID 9533033.

[pmid10467730-6] Foulon T, Cadel S, Cohen P (Oct 1999). "Aminopeptidase B (EC 3.4.11.6)". Int J Biochem Cell Biol. 31 (7): 747–50. doi:10.1016/S1357-2725(99)00021-7. PMID 10467730.

[entrez-7] "Entrez Gene: RNPEP arginyl aminopeptidase (aminopeptidase B)".

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading

External links