ROCK2

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ROCK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2
External IDsMGI: 107926 HomoloGene: 21010 GeneCards: ROCK2
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ROCK2
Genomic location for ROCK2
Band2p25.1Start11,179,761 bp[1]
End11,348,330 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004850
NM_001321643

NM_009072

RefSeq (protein)

NP_001308572
NP_004841

NP_033098

Location (UCSC)Chr 2: 11.18 – 11.35 MbChr 12: 16.89 – 16.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. [5]

Function[edit]

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134318 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020580 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21.

Further reading[edit]

  • Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". Biochemistry. 41 (28): 8948–53. doi:10.1021/bi0258243. PMID 12102637.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.