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Ribosomal protein L22
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPL22 ; EAP; HBP15; HBP15/L22; L22
External IDs OMIM180474 MGI99262 HomoloGene37378 GeneCards: RPL22 Gene
RNA expression pattern
PBB GE RPL22 208768 x at tn.png
PBB GE RPL22 214042 s at tn.png
PBB GE RPL22 220960 x at tn.png
More reference expression data
Species Human Mouse
Entrez 6146 19934
Ensembl ENSG00000116251 ENSMUSG00000028936
UniProt P35268 P67984
RefSeq (mRNA) NM_000983 NM_001277113
RefSeq (protein) NP_000974 NP_001264042
Location (UCSC) Chr 1:
6.18 – 6.21 Mb
Chr 4:
152.33 – 152.33 Mb
PubMed search [1] [2]

60S ribosomal protein L22 is a protein that in humans is encoded by the RPL22 gene.[1][2]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2.[2]


Further reading[edit]