Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Seshadri T, Uzman JA, Oshima J, Campisi J (1993). "Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene". J. Biol. Chem. 268 (25): 18474–80. PMID8360149.
De Falco S, Russo G, Angiolillo A, Pietropaolo C (1993). "Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene". Gene. 126 (2): 227–35. doi:10.1016/0378-1119(93)90371-9. PMID8482538.
Yon J, Jones T, Garson K, et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum. Mol. Genet. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID8499913.
Nicoloso M, Qu LH, Michot B, Bachellerie JP (1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". J. Mol. Biol. 260 (2): 178–95. doi:10.1006/jmbi.1996.0391. PMID8764399.
Russo G, Ricciardelli G, Pietropaolo C (1997). "Different domains cooperate to target the human ribosomal L7a protein to the nucleus and to the nucleoli". J. Biol. Chem. 272 (8): 5229–35. doi:10.1074/jbc.272.8.5229. PMID9030593.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Gilley J, Fried M (1998). "Evolution of U24 and U36 snoRNAs encoded within introns of vertebrate rpL7a gene homologs: unique features of mammalian U36 variants". DNA Cell Biol. 17 (7): 591–602. doi:10.1089/dna.1998.17.591. PMID9703018.