60S ribosomal protein L8

From Wikipedia, the free encyclopedia
  (Redirected from RPL8)
Jump to: navigation, search
RPL8
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RPL8, L8, ribosomal protein L8
External IDs MGI: 1350927 HomoloGene: 32141 GeneCards: RPL8
RNA expression pattern
PBB GE RPL8 200936 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000973
NM_033301
NM_001317771
NM_001317782

NM_012053

RefSeq (protein)

NP_000964
NP_001304700
NP_001304711
NP_150644

NP_036183.1
NP_036183

Location (UCSC) Chr 8: 144.79 – 144.79 Mb Chr 15: 76.9 – 76.91 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L8 is a protein that in humans is encoded by the RPL8 gene.[3][4][5]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hanes J, Klaudiny J, von der Kammer H, Scheit KH (Feb 1994). "Characterization by cDNA cloning of the mRNA of human ribosomal protein L8". Biochem Biophys Res Commun. 197 (3): 1223–8. doi:10.1006/bbrc.1993.2607. PMID 7506540. 
  4. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  5. ^ a b "Entrez Gene: RPL8 ribosomal protein L8". 

Further reading[edit]