RPLP0

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RPLP0
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPLP0, L10E, LP0, P0, PRLP0, RPP0, ribosomal protein lateral stalk subunit P0
External IDsMGI: 1927636 HomoloGene: 6517 GeneCards: RPLP0
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for RPLP0
Genomic location for RPLP0
Band12q24.23Start120,196,686 bp[1]
End120,201,235 bp[1]
RNA expression pattern
PBB GE RPLP0 208856 x at fs.png

PBB GE RPLP0 214167 s at fs.png

PBB GE RPLP0 201033 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_053275
NM_001002

NM_007475

RefSeq (protein)

NP_000993
NP_444505
NP_000993.1
NP_444505.1

NP_031501

Location (UCSC)Chr 12: 120.2 – 120.2 MbChr 5: 115.56 – 115.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

60S acidic ribosomal protein P0 is a protein that in humans is encoded by the RPLP0 gene.[5][6]

Ribosomes catalyze protein synthesis and consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089157 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067274 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  6. ^ a b "Entrez Gene: RPLP0 ribosomal protein, large, P0". 

Further reading[edit]