60S acidic ribosomal protein P2

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PDB 1s4j EBI.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Aliases RPLP2, D11S2243E, LP2, P2, RPP2, ribosomal protein lateral stalk subunit P2
External IDs MGI: 1914436 HomoloGene: 133574 GeneCards: RPLP2
RNA expression pattern
PBB GE RPLP2 200909 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 0.81 – 0.81 Mb Chr 7: 141.45 – 141.45 Mb
PubMed search [1] [2]
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60S acidic ribosomal protein P2 is a protein that in humans is encoded by the RPLP2 gene.[3][4]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the Escherichia coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[4]


RPLP2 has been shown to interact with RPLP1.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Rich BE, Steitz JA (March 1988). "Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly". Mol Cell Biol. 7 (11): 4065–74. PMC 368077Freely accessible. PMID 3323886. 
  4. ^ a b "Entrez Gene: RPLP2 ribosomal protein, large, P2". 
  5. ^ Tchórzewski, M; Boldyreff B; Issinger O G; Grankowski N (July 2000). "Analysis of the protein-protein interactions between the human acidic ribosomal P-proteins: evaluation by the two hybrid system". Int. J. Biochem. Cell Biol. England. 32 (7): 737–746. doi:10.1016/S1357-2725(00)00017-0. PMID 10856704. 

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