RPN1

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RPN1
Identifiers
Aliases RPN1, OST1, RBPH1, ribophorin I
External IDs MGI: 98084 HomoloGene: 2213 GeneCards: RPN1
RNA expression pattern
PBB GE RPN1 201011 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002950

NM_133933

RefSeq (protein)

NP_002941

NP_598694.3
NP_598694

Location (UCSC) Chr 3: 128.62 – 128.68 Mb Chr 6: 88.08 – 88.11 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 1 is an enzyme that in humans is encoded by the RPN1 gene.[3]

This gene encodes a type I integral ribophorin membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein should not be confused with RPN1 of yeast, Drosophila, and C. elegans, which forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. The human version of this proteasome subunit is PSMD2.[3]

References[edit]

Further reading[edit]