Ribosomes, the organelles that catalyzeprotein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
^Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. PMID9582194. doi:10.1101/gr.8.5.509.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144–9. PMID8706699. doi:10.1111/j.1432-1033.1996.0144u.x.
Kenmochi N, Higa S, Yoshihama M, Tanaka T (1996). "U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene.". Biochem. Biophys. Res. Commun. 228 (2): 371–4. PMID8920921. doi:10.1006/bbrc.1996.1668.
Caldwell GM, Eddy RL, Day CD, et al. (2001). "Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1→p14.". Cytogenet. Cell Genet. 92 (1-2): 103–7. PMID11306805. doi:10.1159/000056877.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. PMID14743216. doi:10.1038/ncb1086.
Shi Y, Zhai H, Wang X, et al. (2004). "Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis.". Exp. Cell Res. 296 (2): 337–46. PMID15149863. doi:10.1016/j.yexcr.2004.02.009.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. PMID15592455. doi:10.1038/nbt1046.
Malygin A, Parakhnevitch N, Karpova G (2005). "Human ribosomal protein S13: cloning, expression, refolding, and structural stability.". Biochim. Biophys. Acta. 1747 (1): 93–7. PMID15680243. doi:10.1016/j.bbapap.2004.10.001.