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Ribosomal protein S25
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPS25 ; S25
External IDs OMIM180465 MGI1922867 HomoloGene133893 GeneCards: RPS25 Gene
Species Human Mouse
Entrez 6230 75617
Ensembl ENSG00000118181 ENSMUSG00000009927
UniProt P62851 P62852
RefSeq (mRNA) NM_001028 NM_024266
RefSeq (protein) NP_001019 NP_077228
Location (UCSC) Chr 11:
119.02 – 119.02 Mb
Chr 9:
44.41 – 44.41 Mb
PubMed search [1] [2]

40S ribosomal protein S25 is a protein that in humans is encoded by the RPS25 gene.[1][2]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[2]


RPS25 has been shown to interact with CDC5L.[3]


  1. ^ Li ML, Latoud C, Center MS (January 1992). "Cloning and sequencing a cDNA encoding human ribosomal protein S25". Gene 107 (2): 329–33. doi:10.1016/0378-1119(91)90335-9. PMID 1748303. 
  2. ^ a b "Entrez Gene: RPS25 ribosomal protein S25". 
  3. ^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. 

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