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Ribosomal protein S27a
Protein RPS27A PDB 1aar.png
PDB rendering based on 1aar.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPS27A ; CEP80; HEL112; S27A; UBA80; UBC; UBCEP1; UBCEP80
External IDs OMIM191343 MGI1925544 HomoloGene37715 GeneCards: RPS27A Gene
Species Human Mouse
Entrez 6233 78294
Ensembl ENSG00000143947 ENSMUSG00000020460
UniProt P62979 P62983
RefSeq (mRNA) NM_001135592 NM_001033865
RefSeq (protein) NP_001129064 NP_001029037
Location (UCSC) Chr 2:
55.23 – 55.24 Mb
Chr 11:
29.55 – 29.55 Mb
PubMed search [1] [2]

40S ribosomal protein S27a is a protein that in humans is encoded by the RPS27A gene.[1][2]

Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi.[2]


  1. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  2. ^ a b "Entrez Gene: RPS27A ribosomal protein S27a". 

Further reading[edit]