40S ribosomal protein S3

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Protein RPS3 PDB 1wh9.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases RPS3, S3, ribosomal protein S3
External IDs MGI: 1350917 HomoloGene: 779 GeneCards: RPS3
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for RPS3
Genomic location for RPS3
Band 11q13.4 Start 75,399,486 bp[1]
End 75,422,280 bp[1]
RNA expression pattern
PBB GE RPS3 208692 at fs.png

PBB GE RPS3 214208 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 75.4 – 75.42 Mb Chr 11: 99.48 – 99.48 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

40S ribosomal protein S3 is a protein that in humans is encoded by the RPS3 gene.[5][6][7]


Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149273 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030744 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Pogue-Geile K, Geiser JR, Shu M, Miller C, Wool IG, Meisler AI, Pipas JM (Aug 1991). "Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein". Mol. Cell. Biol. 11 (8): 3842–9. PMC 361167Freely accessible. PMID 1712897. 
  6. ^ Polakiewicz RD, Munroe DJ, Sait SN, Tycowski KT, Nowak NJ, Shows TB, Housman DE, Page DC (Jul 1995). "Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3-q13.5". Genomics. 25 (2): 577–80. doi:10.1016/0888-7543(95)80063-R. PMID 7789996. 
  7. ^ a b "Entrez Gene: RPS3 ribosomal protein S3". 

Further reading[edit]