RPS6KA2

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RPS6KA2
Identifiers
AliasesRPS6KA2, HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3, p90RSK2, ribosomal protein S6 kinase A2
External IDsMGI: 1342290 HomoloGene: 100680 GeneCards: RPS6KA2
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for RPS6KA2
Genomic location for RPS6KA2
Band6q27Start166,409,364 bp[1]
End166,906,451 bp[1]
RNA expression pattern
PBB GE RPS6KA2 204906 at fs.png

PBB GE RPS6KA2 212912 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001006932
NM_021135
NM_001318936
NM_001318937
NM_001318938

NM_011299

RefSeq (protein)

NP_001006933
NP_001305865
NP_001305866
NP_001305867
NP_066958

NP_035429

Location (UCSC)Chr 6: 166.41 – 166.91 MbChr 17: 7.17 – 7.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.[5][6]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine and threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

Interactions[edit]

RPS6KA2 has been shown to interact with MAPK3[7][8] and MAPK1.[7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000071242 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023809 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (Apr 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". Am J Physiol. 266 (2 Pt 1): C351–9. PMID 8141249.
  6. ^ a b "Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2".
  7. ^ a b Roux, Philippe P; Richards Stephanie A; Blenis John (Jul 2003). "Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity". Mol. Cell. Biol. United States. 23 (14): 4796–804. doi:10.1128/MCB.23.14.4796-4804.2003. ISSN 0270-7306. PMC 162206. PMID 12832467.
  8. ^ a b Zhao, Y; Bjorbaek C; Moller D E (Nov 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". J. Biol. Chem. UNITED STATES. 271 (47): 29773–9. doi:10.1074/jbc.271.47.29773. ISSN 0021-9258. PMID 8939914.

Further reading[edit]