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Ribosomal protein S6 kinase, 90kDa, polypeptide 2
Symbols RPS6KA2 ; HU-2; MAPKAPK1C; RSK; RSK3; S6K-alpha; S6K-alpha2; p90-RSK3; pp90RSK3
External IDs OMIM601685 MGI1342290 HomoloGene100680 ChEMBL: 3906 GeneCards: RPS6KA2 Gene
EC number
RNA expression pattern
PBB GE RPS6KA2 204906 at tn.png
PBB GE RPS6KA2 212912 at tn.png
More reference expression data
Species Human Mouse
Entrez 6196 20112
Ensembl ENSG00000071242 ENSMUSG00000023809
UniProt Q15349 Q9WUT3
RefSeq (mRNA) NM_001006932 NM_011299
RefSeq (protein) NP_001006933 NP_035429
Location (UCSC) Chr 6:
166.41 – 166.91 Mb
Chr 17:
7.17 – 7.3 Mb
PubMed search [1] [2]

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.[1][2]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine and threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]


RPS6KA2 has been shown to interact with MAPK3[3][4] and MAPK1.[3][4]


  1. ^ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (Apr 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". Am J Physiol 266 (2 Pt 1): C351–9. PMID 8141249. 
  2. ^ a b "Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2". 
  3. ^ a b Roux, Philippe P; Richards Stephanie A; Blenis John (Jul 2003). "Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity". Mol. Cell. Biol. (United States) 23 (14): 4796–804. doi:10.1128/MCB.23.14.4796-4804.2003. ISSN 0270-7306. PMC 162206. PMID 12832467. 
  4. ^ a b Zhao, Y; Bjorbaek C; Moller D E (Nov 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". J. Biol. Chem. (UNITED STATES) 271 (47): 29773–9. doi:10.1074/jbc.271.47.29773. ISSN 0021-9258. PMID 8939914. 

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