RPS6KA4

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RPS6KA4
Identifiers
Aliases RPS6KA4, MSK2, RSK-B, S6K-alpha-4, ribosomal protein S6 kinase A4
External IDs MGI: 1930076 HomoloGene: 69288 GeneCards: RPS6KA4
Genetically Related Diseases
leprosy, primary biliary cirrhosis[1]
RNA expression pattern
PBB GE RPS6KA4 204632 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001006944
NM_001300802
NM_003942
NM_001318361

NM_019924

RefSeq (protein)

NP_001006945
NP_001287731
NP_001305290
NP_003933

NP_064308.2
NP_064308

Location (UCSC) Chr 11: 64.36 – 64.37 Mb Chr 19: 6.83 – 6.84 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.[4][5][6]

Function[edit]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[6]

Interactions[edit]

RPS6KA4 has been shown to interact with MAPK14.[4]

References[edit]

  1. ^ "Diseases that are genetically associated with RPS6KA4 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec 1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J Biol Chem. 273 (45): 29661–29671. doi:10.1074/jbc.273.45.29661. PMID 9792677. 
  5. ^ Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC 1170775Freely accessible. PMID 9687510. 
  6. ^ a b "Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4". 

Further reading[edit]