RPS6KA4

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RPS6KA4
Identifiers
Aliases RPS6KA4, MSK2, RSK-B, S6K-alpha-4, ribosomal protein S6 kinase A4
External IDs MGI: 1930076 HomoloGene: 69288 GeneCards: 8986
Genetically Related Diseases
Disease Name References
leprosy
primary biliary cirrhosis
RNA expression pattern
PBB GE RPS6KA4 204632 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001006944
NM_001300802
NM_003942
NM_001318361

NM_019924

RefSeq (protein)

NP_001006945.1
NP_001287731.1
NP_003933.1
NP_001305290.1

NP_064308.2

Location (UCSC) Chr 11: 64.36 – 64.37 Mb Chr 19: 6.83 – 6.84 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.[5][6][7]

Function[edit]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[7]

Interactions[edit]

RPS6KA4 has been shown to interact with MAPK14.[5]

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_1024&geneId=188471". 
  2. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_12236&geneId=188471". 
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec 1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J Biol Chem. 273 (45): 29661–29671. doi:10.1074/jbc.273.45.29661. PMID 9792677. 
  6. ^ Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC 1170775free to read. PMID 9687510. 
  7. ^ a b "Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4". 

Further reading[edit]