RRM1

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RRM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRRM1, R1, RIR1, RR1, ribonucleotide reductase catalytic subunit M1
External IDsOMIM: 180410 MGI: 98180 HomoloGene: 806 GeneCards: RRM1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for RRM1
Genomic location for RRM1
Band11p15.4Start4,094,707 bp[1]
End4,138,932 bp[1]
RNA expression pattern
PBB GE RRM1 201476 s at fs.png

PBB GE RRM1 201477 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033
NM_001318064
NM_001318065
NM_001330193

NM_009103

RefSeq (protein)

NP_001024
NP_001304993
NP_001304994
NP_001317122

NP_033129

Location (UCSC)Chr 11: 4.09 – 4.14 MbChr 7: 102.44 – 102.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene.[5][6]

This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.[6]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:
FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167325 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030978 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Parker NJ, Begley CG, Fox RM (Nov 1995). "Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter". Genomics. 27 (2): 280–5. doi:10.1006/geno.1995.1043. PMID 7557993.
  6. ^ a b "Entrez Gene: RRM1 ribonucleotide reductase M1 polypeptide".

Further reading[edit]