RRNA N-glycosylase

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rRNA N-glycosylase
1il3.jpg
Ricin A chain, Ricinus communis
Identifiers
EC number3.2.2.22
CAS number113756-12-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

rRNA N-glycosylase (EC 3.2.2.22, ribosomal ribonucleate N-glycosidase, nigrin b, RNA N-glycosidase, rRNA N-glycosidase, ricin, momorcochin-S, Mirabilis antiviral protein, gelonin, saporins) is an enzyme with systematic name rRNA N-glycohydrolase.[1] This enzyme catalyses the following chemical reaction

Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from eukaryotic ribosomes.

Ricin A-chain and related toxins show this activity.

References[edit]

  1. ^ Endo Y, Tsurugi K (June 1988). "The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA". The Journal of Biological Chemistry. 263 (18): 8735–9. PMID 3288622.

External links[edit]