RTI-171

From Wikipedia, the free encyclopedia
Jump to: navigation, search
RTI-171
RTI-171 structure.png
Systematic (IUPAC) name
3-methyl-5-[(1S,3S,4S,5R)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-4-yl]-1,2-oxazole
Identifiers
PubChem CID 10565888
ChemSpider 8741276
Chemical data
Formula C19H24N2O
Molar mass 296.406 g/mol
  (verify)

(–)-2β-(3-Methylisoxazol-5-yl)-3β-(p-tolyl)tropane (RTI-4229-171) is a phenyltropane derivative which acts as a selective dopamine reuptake inhibitor, with a relatively slow onset of action and short duration of effects found in animal studies.[1] However, other studies have shown it to have the most pronounced effects in terms of speed of onset and rate of stimulation among many differing phenyltropanes.[2]

See also[edit]

References[edit]

  1. ^ Kimmel HL, Carroll FI, Kuhar MJ (December 2001). "Locomotor stimulant effects of novel phenyltropanes in the mouse". Drug and Alcohol Dependence. 65 (1): 25–36. doi:10.1016/S0376-8716(01)00144-2. PMID 11714587. 
  2. ^ Kimmel, Heather L.; O'Connor, Joann A.; Carroll, F. Ivy; Howell, Leonard L. (2007). "Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys". Pharmacology Biochemistry and Behavior. 86 (1): 45–54. doi:10.1016/j.pbb.2006.12.006. ISSN 0091-3057.