RTKN

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RTKN
Identifiers
Aliases RTKN
External IDs MGI: 107371 HomoloGene: 7522 GeneCards: RTKN
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001015055
NM_001015056
NM_033046

NM_001136227
NM_009106
NM_133641

RefSeq (protein)

NP_001015055
NP_001015056
NP_149035

Location (UCSC) Chr 2: 74.43 – 74.44 Mb Chr 6: 83.14 – 83.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Rhotekin is a protein that in humans is encoded by the RTKN gene.[3][4][5]

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Jang W, Weber JS, Harkins EB, Meisler MH (May 1997). "Localization of the rhotekin gene RTKN on the physical maps of mouse chromosome 6 and human chromosome 2p13 and exclusion as a candidate for mnd2 and LGMD2B". Genomics. 40 (3): 506–7. doi:10.1006/geno.1996.4593. PMID 9073523. 
  4. ^ Reynaud C, Fabre S, Jalinot P (Nov 2000). "The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element". J Biol Chem. 275 (43): 33962–8. doi:10.1074/jbc.M000465200. PMID 10940294. 
  5. ^ a b "Entrez Gene: RTKN rhotekin". 

Further reading[edit]