|Drug class||Nonsteroidal antiandrogen|
|Chemical and physical data|
|Molar mass||369.3 g/mol|
|3D model (JSmol)|
RU-58841 (also known as PSK-3841 or HMR-3841) is a nonsteroidal antiandrogen (NSAA) which was previously investigated for use as a topical treatment for acne, androgenetic alopecia, and hirsutism. The compound is similar in structure to RU-58642 but contains a different side-chain. These compounds are similar in chemical structure to nilutamide, which is related to flutamide, bicalutamide, and enzalutamide. RU-58841 can be synthesized either by building the hydantoin moiety or by aryl coupling to 5,5-dimethylhydantoin 
RU-58841 as a possible treatment for hair loss
RU58841 is considered to be one of the most promising drugs regarding hair loss prevention. To study the effect of the RU58841 on human hair growth, researchers (Brouwer et al., 1997) used twenty productive scalp grafts from balding men. The grafts that were treated with a solution of RU58841 had a total of 29 active follicles while the control grafts had two follicles.
- Battmann, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D (January 1994). "RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism". Journal of Steroid Biochemistry and Molecular Biology. 48 (1): 55–60. PMID 8136306. doi:10.1016/0960-0760(94)90250-x.
- Münster U; Nakamura C; Haberland A; Jores K; Mehnert W; Rummel S; Schaller M; Korting HC; Zouboulis ChC; Blume-Peytavi U; Schäfer-Korting M (January 2005). "RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia". Pharmazie. 60 (1): 8–12. PMID 15700772.
- Van Dort ME, Jung YW (2001). "Synthesis and structure–activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands". Bioorg. Med. Chem. Lett. 11 (8): 1045–1047. PMID 11327585. doi:10.1016/s0960-894x(01)00146-9.
- "Investigational medications in the treatment of alopecia". Expert Opinion on Investigational Drugs. 14 (2): 177–184. February 2005. doi:10.1517/135437184.108.40.206.
- M. J. Leonard, A. R. Lingham, J. O. Niere, N. R. C. Jackson, P. G. McKay and H. M. Hϋgel (6 Mar 2014). "Alternative synthesis of the anti-baldness compound RU58841". RSC Advances. 4: 14143–14148. doi:10.1039/c4ra00332b.
- "RU58841 for Hair Loss / Increasing Hair growth". 2016-10-03. Retrieved 2017-04-30.
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