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Protein RUVBL2 PDB 2cqa.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases RUVBL2, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B, CGI-46, ECP-51, TAP54-beta, RuvB like AAA ATPase 2
External IDs MGI: 1342299 HomoloGene: 4856 GeneCards: 10856
RNA expression pattern
PBB GE RUVBL2 201459 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 48.99 – 49.02 Mb Chr 7: 45.42 – 45.43 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.


This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory.[1] This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.[2]


RUVBL2 has been shown to interact with RuvB-like 1[3] and Activating transcription factor 2.[4]


  1. ^ Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR (Feb 2007). "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex". Journal of Molecular Biology 366 (1): 179–92. doi:10.1016/j.jmb.2006.11.030. PMID 17157868. 
  2. ^ "Entrez Gene: RUVBL2 RuvB-like 2 (E. coli)". 
  3. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  4. ^ Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z (Dec 2001). "TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage". Molecular and Cellular Biology 21 (24): 8398–413. doi:10.1128/MCB.21.24.8398-8413.2001. PMC 100004. PMID 11713276. 

Further reading[edit]