Raf kinase inhibitor protein

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The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell.[1] RKIP is a member of the phosphatidylethanolamine-binding protein family and has displayed disruptive regulation on the Raf-1-MEK1/2, ERK1/2 and NF-kappaB signalling pathways, by interaction with the Raf-1 kinase.[2] RKIP has also been shown to inhibit G protein coupled receptor kinases (GRK) when phosphorylated by protein kinase C.[3] Via this mechanism it has been shown to exert beneficial effects on cardiac structure and function.[4]

References[edit]

  1. ^ Odabaei, G.; Chatterjee, D.; Jazirehi, A. R.; Goodglick, L.; Yeung, K.; Bonavida, B. (2004). "Raf-1 Kinase Inhibitor Protein: Structure, Function, Regulation of Cell Signaling, and Pivotal Role in Apoptosis". Advances in Cancer Research. Advances in Cancer Research. 91: 169–200. doi:10.1016/S0065-230X(04)91005-6. ISBN 9780120066919. PMID 15327891.
  2. ^ Odabaei, Golaun (2004). "Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis". Advances in Cancer Research. 91: 91:169–200. doi:10.1016/S0065-230X(04)91005-6. PMID 15327891.
  3. ^ Lorenz K, Lohse MJ, Quitterer U (2003): Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature 426: 574-579.
  4. ^ Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K (2015): Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nature Medicine doi: 10.1038/nm.3972.