Ramanujan Hegde

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Ramanujan Hegde

Dr Ramanujan Hegde FRS.jpg
Ramanujan Hegde at the Royal Society admissions day in London, July 2016
Ramanujan Shankar Hegde

(1970-04-01) 1 April 1970 (age 49)[1]
Alma mater
AwardsEMBO Member (2013)
Scientific career
ThesisThe regulation of protein translocation at the endoplasmic reticulum (1998)
Doctoral advisorVishwanath R. Lingappa[3]

Ramanujan Shankar Hegde (born 1970)[1] FRS[4] is a group leader in the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge.[5][6]


Hegde was educated at the University of Chicago[2] where he was awarded a Bachelor of Arts degree[1][when?] and the University of California, San Francisco where he was awarded a Doctor of Medicine (MD) degree in 1999 and PhD in 1998 for research on protein targeting and translocation at the endoplasmic reticulum supervised by Vishwanath R. Lingappa.[2][3]

Research and career[edit]

Hegde's research[7] investigates how proteins are localised correctly inside cells, and how errors during protein maturation are recognised and disposed. These processes are important because the accumulation of abnormal proteins is disruptive to cell function, and underlies numerous diseases.[4]

His laboratory have discovered a widely conserved protein targeting pathway[8] needed by a subset of proteins to reach their correct membrane-embedded destination. Their studies of such protein targeting pathways are revealing how membrane proteins are accurately recognised by the machinery responsible for their proper localisation and insertion. Hegde's work has also shown that even modest failures of individual proteins to reach their correct cellular location can lead to neurodegeneration, and that cells have specialised pathways to identify these wayward proteins and target them for destruction.[4]

As of 2016, according to Google Scholar[9] his most cited research include papers published in Science,[10][11] Nature,[12] and Cell.[8] His research has been funded by the Medical Research Council.[13]

Ramanujan Hegde in 2001

Awards and honours[edit]

Hegde was awarded the R.R. Bensley award in Cell Biology in 2008[citation needed] and elected a member of the European Molecular Biology Organisation (EMBO) in 2013.[4] He was also elected a Fellow of the Royal Society (FRS) in 2016.[4]


  1. ^ a b c d Anon (2017). Hegde, Dr Ramanujan S. ukwhoswho.com. Who's Who (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. doi:10.1093/ww/9780199540884.013.U287290. (subscription or UK public library membership required) (subscription required)
  2. ^ a b c Sedwick, Caitlin (2010). "Ramanujan Hegde: The prion puzzle and protein translocation". The Journal of Cell Biology. 191 (7): 1222–1223. doi:10.1083/jcb.1917pi. PMC 3010069. PMID 21187325.
  3. ^ a b Hegde, Ramanujan Shankar (1998). The regulation of protein translocation at the endoplasmic reticulum (PhD thesis). proquest.com. OCLC 50795524.
  4. ^ a b c d e Anon (2016). "Dr Ramanujan Hegde FRS". London: royalsociety.org. Archived from the original on 29 April 2016. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --"Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved 9 March 2016.CS1 maint: BOT: original-url status unknown (link)

  5. ^ Anon (2016). "Ramanujan Hegde MRC Laboratory of Molecular Biology: Membrane protein biosynthesis and quality control". Cambridge: University of Cambridge. Archived from the original on 13 April 2016.
  6. ^ Anon (2016). "Hegde Lab: Protein biosynthesis & quality control". mrc-lmb.cam.ac.uk. Retrieved 22 December 2016.
  7. ^ Ramanujan Hegde publications from Europe PubMed Central
  8. ^ a b Stefanovic, Sandra; Hegde, Ramanujan S. (2007). "Identification of a targeting factor for posttranslational membrane protein insertion into the ER". Cell. 128: 1147–1159. doi:10.1016/j.cell.2007.01.036. PMID 17382883.
  9. ^ "Ramanujan Hegde publications in Google Scholar". Google Scholar.
  10. ^ Hegde, R. S. (1998). "A Transmembrane Form of the Prion Protein in Neurodegenerative Disease". Science. 279 (5352): 827–834. doi:10.1126/science.279.5352.827. PMID 9452375.
  11. ^ "Ramanujan S. Hegde". sciencemag.org.
  12. ^ Hegde, Ramanujan S.; Tremblay, Patrick; Groth, Darlene; DeArmond, Stephen J.; Prusiner, Stanley B.; Lingappa, Vishwanath R. (1999). "Transmissible and genetic prion diseases share a common pathway of neurodegeneration". Nature. 402 (6763): 822–826. doi:10.1038/45574. PMID 10617204.
  13. ^ Anon (2016). "UK Government Grants awarded to Ramanujan Hegde". Swindon: Research Councils UK. Archived from the original on 4 May 2016.