Rancho Huichica was a 18,704-acre (75.69 km2) Mexican land grant in present day Napa County, California given in 1841 to Jacob P. Leese. Carneros Creek forms the northeast boundary of Rancho Huichica, and the grant contains the majority of the Carneros region in Napa Valley.
Leese was a San Francisco pioneer who built the first permanent house in San Francisco. He married General Vallejo’s sister, and moved to Sonoma in 1841. In 1841 Manuel Jimeno, acting Governor of California, granted two square leagues to Leese, and in 1844 Governor Manuel Micheltorena granted Leese a three and a half leagues extension. 
With the cession of California to the United States following the Mexican-American War, the 1848 Treaty of Guadalupe Hidalgo provided that the land grants would be honored. As required by the Land Act of 1851, a claim for Rancho Huichica was filed with the Public Land Commission in 1852, and the grant was patented to Jacob P. Leese in 1859.
In the mid-1850s, William H. Winter of Indiana purchased 1,200 acres (5 km2) of the Rancho Huichica from Leese. The first winery in Carneros, Winter Winery was then established during the early 1870s. Beginning in the 1880s Phylloxera devastated many of the vineyards in the Carneros region. The Winter Winery was sold in 1881 to James Simonton who changed the name to Talcoa Vineyards. Simonton became the first to experiment scientifically, under the direction of Missouri viticulturist George Husmann, to find Phylloxera-resistant rootstock.
Around 1857 Jacob Gundlach and Emil Dresel purchased 400 acres (1.6 km2) of Rancho Huichica. Jacob Gundlach, the son of a Bavarian hotel keeper, came to California in 1850 at age 33, lured by the promise of gold. He became successful making beer, founding the Bavarian Brewery of San Francisco. Sometime after 1851 he became associated with Emil Dresel, an architect from Geisenheim, Germany. Around 1857 Gundlach and Dresel purchased 400 acres (1.6 km2) of Rancho Huichica, named it Rhinefarm, and turned to winemaking. In 1864, Charles Bundschu came from Germany to work for Gundlach, and married Gundlach's daughter. Dresel and Gundlach separated their operation sometime after 1869, and in 1894 the firm of J. Gundlach & Co. became Gundlach-Bundschu.
- Ogden Hoffman, 1862, Reports of Land Cases Determined in the United States District Court for the Northern District of California, Numa Hubert, San Francisco
- Diseño del Rancho Huichica
- Hale v. Akers, 132 U.S. 554 (1889)
- Hoover, Mildred B.; Rensch, Hero; Rensch, Ethel; Abeloe, William N. (1966). Historic Spots in California. Stanford University Press. ISBN 978-0-8047-4482-9.
- Lyman L. Palmer, 1881,History of Napa and Lake Counties, California, Slocum, Bowen & Co.
- United States. District Court (California : Northern District) Land Case 50 ND
- Report of the Surveyor General 1844 - 1886 Archived 2013-03-20 at the Wayback Machine