Randy Read

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Randy Read

Professor Randy Read FRS.jpg
Randy Read at the Royal Society admissions day in London, July 2014
Born
Randy John Read

(1957-06-09) 9 June 1957 (age 62)[1]
Alma materUniversity of Alberta (BSc, PhD)
Known for
  • Phaser[2]
  • PHENIX (Python-based Hierarchical ENvironment for Integrated Xtallography)[3][4]
AwardsWellcome Trust Principal Research Fellow
Scientific career
Fields
InstitutionsUniversity of Cambridge
ThesisX-ray crystallographic studies on serine proteinases and their protein inhibitors (1986)
Doctoral advisorMichael N. G. James[6][7]
Websitewww.cimr.cam.ac.uk/research/principal-investigators/principal-investigators-q-z/read

Randy John Read FRS[8] (born 9 June 1957)[1] is a Wellcome Trust Principal Research Fellow and Professor of Protein Crystallography at the University of Cambridge.[5][9][10][11]

Education[edit]

Read was educated at the University of Alberta in Edmonton, Canada where he was awarded a Bachelor of Science degree in 1979 followed by a PhD in 1986[1] for X-ray crystallography of serine proteases and their protein kinase inhibitors supervised by Michael N. G. James.[6][7]

Career and research[edit]

Following his PhD, Read was appointed Assistant Professor from 1988 to 1993 and Associate Professor from 1993 to 1998 at the University of Alberta.[1] As of 2017, Read's research interests are in protein crystallography and maximum likelihood estimation.[5] His research has been published in leading peer reviewed scientific journals including Nature,[12][13][14] Science,[15] the Journal of Applied Crystallography[2] Acta Crystallographica,[4][16][17] Structure,[18][19] PNAS,[20] the Journal of Molecular Biology[21][22] and the Journal of Clinical Endocrinology and Metabolism.[23]

Awards and honours[edit]

Read was elected Fellow of the Royal Society (FRS) in 2014. His nomination reads:

References[edit]

  1. ^ a b c d Anon (2014). "Read, Prof. Randy John". Who's Who. ukwhoswho.com (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. doi:10.1093/ww/9780199540884.013.43034. (subscription or UK public library membership required) (subscription required)
  2. ^ a b McCoy, A. J.; Grosse-Kunstleve, R. W.; Adams, P. D.; Winn, M. D.; Storoni, L. C.; Read, R. J. (2007). "Phaser crystallographic software". Journal of Applied Crystallography. 40 (4): 658–674. CiteSeerX 10.1.1.322.8550. doi:10.1107/S0021889807021206.
  3. ^ Adams, P. D.; Grosse-Kunstleve, R. W.; Hung, L. W.; Ioerger, T. R.; McCoy, A. J.; Moriarty, N. W.; Read, R. J.; Sacchettini, J. C.; Sauter, N. K.; Terwilliger, T. C. (2002). "PHENIX: Building new software for automated crystallographic structure determination". Acta Crystallographica Section D. 58 (11): 1948–1954. doi:10.1107/S0907444902016657.
  4. ^ a b Adams, P. D.; Afonine, P. V.; Bunkóczi, G. B.; Chen, V. B.; Davis, I. W.; Echols, N.; Headd, J. J.; Hung, L. W.; Kapral, G. J.; Grosse-Kunstleve, R. W.; McCoy, A. J.; Moriarty, N. W.; Oeffner, R.; Read, R. J.; Richardson, D. C.; Richardson, J. S.; Terwilliger, T. C.; Zwart, P. H. (2010). "PHENIX: A comprehensive Python-based system for macromolecular structure solution". Acta Crystallographica Section D. 66 (2): 213–21. doi:10.1107/S0907444909052925. PMC 2815670. PMID 20124702.
  5. ^ a b c Randy Read publications indexed by Google Scholar Edit this at Wikidata
  6. ^ a b Fujinaga, Masao; Sielecki, Anita R.; Read, Randy J.; Ardelt, Wojciech; Laskowski, Michael; James, Michael N.G. (1987). "Crystal and molecular structures of the complex of α-chymotrypsin with its inhibitor Turkey ovomucoid third domain at 1.8 Å resolution". Journal of Molecular Biology. 195 (2): 397–418. doi:10.1016/0022-2836(87)90659-0. ISSN 0022-2836. PMID 3477645.
  7. ^ a b Read, Randy John (1986). X-ray crystallographic studies on serine proteinases and their protein inhibitors (PhD thesis). proquest.com. doi:10.7939/R33776175. hdl:10402/era.3098. ProQuest 250072156.
  8. ^ a b Anon (2014). "Professor Randy Read FRS". London: royalsociety.org. Archived from the original on 5 August 2014.
  9. ^ Randy Read publications indexed by the Scopus bibliographic database. (subscription required)
  10. ^ Read, Randy (2017). "Randy Read's Homepage". University of Cambridge. Archived from the original on 15 May 2013.[dead link]
  11. ^ Randy Read publications from Europe PubMed Central
  12. ^ Zhou, A.; Carrell, R. W.; Murphy, M. P.; Wei, Z.; Yan, Y.; Stanley, P. L. D.; Stein, P. E.; Pipkin, F. B.; Read, R. J. (2010). "A redox switch in angiotensinogen modulates angiotensin release". Nature. 468 (7320): 108–11. doi:10.1038/nature09505. PMC 3024006. PMID 20927107.
  13. ^ Dimaio, F.; Terwilliger, T. C.; Read, R. J.; Wlodawer, A.; Oberdorfer, G.; Wagner, U.; Valkov, E.; Alon, A.; Fass, D.; Axelrod, H. L.; Das, D.; Vorobiev, S. M.; Iwaï, H.; Pokkuluri, P. R.; Baker, D. (2011). "Improved molecular replacement by density- and energy-guided protein structure optimization". Nature. 473 (7348): 540–3. doi:10.1038/nature09964. PMC 3365536. PMID 21532589.
  14. ^ Qian, B.; Raman, S.; Das, R.; Bradley, P.; McCoy, A. J.; Read, R. J.; Baker, D. (2007). "High-resolution structure prediction and the crystallographic phase problem". Nature. 450 (7167): 259–64. doi:10.1038/nature06249. PMC 2504711. PMID 17934447.
  15. ^ Jackson, R. N.; Golden, S. M.; Van Erp, P. B.; Carter, J; Westra, E. R.; Brouns, S. J.; Van Der Oost, J; Terwilliger, T. C.; Read, R. J.; Wiedenheft, B (2014). "Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli". Science. 345 (6203): 1473–9. doi:10.1126/science.1256328. PMC 4188430. PMID 25103409.
  16. ^ Brünger, A. T.; Adams, P. D.; Clore, G. M.; Delano, W. L.; Gros, P.; Grosse-Kunstleve, R. W.; Jiang, J. S.; Kuszewski, J.; Nilges, M.; Pannu, N. S.; Read, R. J.; Rice, L. M.; Simonson, T.; Warren, G. L. (1998). "Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination". Acta Crystallographica Section D. 54 (5): 905–21. doi:10.1107/S0907444998003254. PMID 9757107.
  17. ^ Read, R. J.; Kleywegt, G. J. (2009). "Case-controlled structure validation". Acta Crystallographica Section D. 65 (Pt 2): 140–7. doi:10.1107/S0907444908041085. PMC 2631636. PMID 19171969.
  18. ^ Read, R. J.; Adams, P. D.; Arendall Wb, 3rd; Brunger, A. T.; Emsley, P; Joosten, R. P.; Kleywegt, G. J.; Krissinel, E. B.; Lütteke, T; Otwinowski, Z; Perrakis, A; Richardson, J. S.; Sheffler, W. H.; Smith, J. L.; Tickle, I. J.; Vriend, G; Zwart, P. H. (2011). "A new generation of crystallographic validation tools for the protein data bank". Structure. 19 (10): 1395–412. doi:10.1016/j.str.2011.08.006. PMC 3195755. PMID 22000512.
  19. ^ Kleywegt, G. J.; Read, R. J. (1997). "Not your average density". Structure. 5 (12): 1557–69. doi:10.1016/s0969-2126(97)00305-5. PMID 9438862.
  20. ^ Deane, J. E.; Graham, S. C.; Kim, N. N.; Stein, P. E.; McNair, R; Cachón-González, M. B.; Cox, T. M.; Read, R. J. (2011). "Insights into Krabbe disease from structures of galactocerebrosidase". Proceedings of the National Academy of Sciences. 108 (37): 15169–73. doi:10.1073/pnas.1105639108. PMC 3174575. PMID 21876145.
  21. ^ Zhou, A; Wei, Z; Stanley, P. L.; Read, R. J.; Stein, P. E.; Carrell, R. W. (2008). "The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release". Journal of Molecular Biology. 380 (1): 244–51. doi:10.1016/j.jmb.2008.05.012. PMID 18513745.
  22. ^ Stoop, A. A.; Eldering, E; Dafforn, T. R.; Read, R. J.; Pannekoek, H (2001). "Different structural requirements for plasminogen activator inhibitor 1 (PAI-1) during latency transition and proteinase inhibition as evidenced by phage-displayed hypermutated PAI-1 libraries". Journal of Molecular Biology. 305 (4): 773–83. doi:10.1006/jmbi.2000.4356. PMID 11162091.
  23. ^ Chan, W. L.; Carrell, R. W.; Zhou, A; Read, R. J. (2013). "How changes in affinity of corticosteroid-binding globulin modulate free cortisol concentration". The Journal of Clinical Endocrinology & Metabolism. 98 (8): 3315–22. doi:10.1210/jc.2012-4280. PMC 3813945. PMID 23783094.