|Trade names||Mucosta (JP), Rebagen (KR, CN, IN), Rebagit (RU)|
|AHFS/Drugs.com||International Drug Names|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||370.786 g/mol g·mol−1|
|3D model (JSmol)|
|(what is this?)|
Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2.
Rebamipide is used in a number of Asian countries including Japan (marketed as Mucosta), South Korea, China and India (where it is marketed under the trade name Rebagen). It is also approved in Russia under the brand name Rebagit. It is not approved by the Food and Drug Administration for use in the United States.
Studies have shown that rebamipide can fight the damaging effects of NSAIDs on the GIT mucosa, and more recently, the small intestine, but not for naproxen-induced gastric damage. It has also been studied for the treatment of Behçet's disease. It was shown to successfully treat pouchitis in a single-N study after first-line therapies for the condition were unsuccessful. Some studies have shown effectiveness in presbyacusis (age-related hearing loss).
- Arakawa T, Kobayashi K, Yoshikawa T, Tarnawski A (September 1998). "Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing". Digestive Diseases and Sciences. 43 (9 Suppl): 5S–13S. PMID 9753220.
- Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K (November 1995). "Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine". Digestive Diseases and Sciences. 40 (11): 2469–72. PMID 7587834.
- Takumida M, Anniko M (January 2009). "Radical scavengers for elderly patients with age-related hearing loss". Acta Oto-Laryngologica. 129 (1): 36–44. doi:10.1080/00016480802008215. PMID 18607930.
- Tarnawski AS, Chai J, Pai R, Chiou SK (February 2004). "Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action?". Digestive Diseases and Sciences. 49 (2): 202–9. PMID 15104358.
- "Rebamipide". Drugs.com.
- "Registration Sertificate: Rebagit (rebamipide) Film-Coated Tablets" (in Russian). Russian State Register of Medicines. Retrieved 10 June 2017.
- Zhang S, Qing Q, Bai Y, Mao H, Zhu W, Chen Q, Zhang Y, Chen Y (July 2013). "Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: a systematic review and meta-analysis". Digestive Diseases and Sciences. 58 (7): 1991–2000. doi:10.1007/s10620-013-2606-0. PMID 23456504.
- Gagliano-Jucá T, Moreno RA, Zaminelli T, Napolitano M, Magalhães AF, Carvalhaes A, Trevisan MS, Wallace JL, De Nucci G (June 2016). "Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial". BMC Gastroenterology. 16 (1): 58. doi:10.1186/s12876-016-0472-x. PMC 4893238. PMID 27259970.
- Matsuda T, Ohno S, Hirohata S, Miyanaga Y, Ujihara H, Inaba G, Nakamura S, Tanaka S, Kogure M, Mizushima Y (2003). "Efficacy of rebamipide as adjunctive therapy in the treatment of recurrent oral aphthous ulcers in patients with Behçet's disease: a randomised, double-blind, placebo-controlled study". Drugs in R&D. 4 (1): 19–28. doi:10.2165/00126839-200304010-00002. PMID 12568631.
- Miyata M, Konagaya T, Kakumu S, Mori T (January 2006). "Successful treatment of severe pouchitis with rebamipide refractory to antibiotics and corticosteroids: a case report". World Journal of Gastroenterology. 12 (4): 656–8. doi:10.3748/wjg.v12.i4.656. PMC 4066106. PMID 16489687.
- Takumida M, Anniko M (December 2005). "Radical scavengers: a remedy for presbyacusis. A pilot study". Acta Oto-Laryngologica. 125 (12): 1290–5. doi:10.1080/00016480510037032. PMID 16303676.
- Kinoshita S, Oshiden K, Awamura S, Suzuki H, Nakamichi N, Yokoi N (June 2013). "A randomized, multicenter phase 3 study comparing 2% rebamipide (OPC-12759) with 0.1% sodium hyaluronate in the treatment of dry eye". Ophthalmology. 120 (6): 1158–65. doi:10.1016/j.ophtha.2012.12.022. PMID 23490326.
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