Redox therapy

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Redox therapy is an experimental therapy[1][2] that aims to effect an outcome by modifying the levels of pro-oxidant and antioxidant agents in cells.[3] The term "redox" is a contraction of "reduction-oxidation". For cancer patients, the therapy is predicated on the idea that the redox state of cells may have an effect on cancer development.[4]

Historically, and in alternative medicine, the term "redox therapy" has also been used to describe the practice of administering high dosages of vitamins; in a 1984 study, high dosages of Menadione and Vitamin C were given to a patient.[5]

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  1. ^ Douglas Robert Spitz; Kenneth J. Dornfeld; Koyamangalath Krishnan; David Gius (25 November 2011). Oxidative Stress in Cancer Biology and Therapy. Springer. p. 75. ISBN 978-1-61779-397-4. Retrieved 17 August 2013.
  2. ^ Cabello, CM; Bair Wb, 3rd; Wondrak, GT (2007). "Experimental therapeutics: Targeting the redox Achilles heel of cancer". Current Opinion in Investigational Drugs. 8 (12): 1022–37. PMID 18058573.
  3. ^ Ogasawara, Marcia A.; Zhang, Hui (2009). "Redox Regulation and Its Emerging Roles in Stem Cells and Stem-Like Cancer Cells". Antioxidants & Redox Signaling. 11 (5): 1107. doi:10.1089/ars.2008.2308.
  4. ^ Chaiswing, Luksana; Zhong, Weixiong; Oberley, Terry D. (2011). "Distinct Redox Profiles of Selected Human Prostate Carcinoma Cell Lines: Implications for Rational Design of Redox Therapy". Cancers. 3 (4): 3557. doi:10.3390/cancers3033557.
  5. ^ Eleff, S. (1984). "31P NMR Study of Improvement in Oxidative Phosphorylation by Vitamins K3 and C in a Patient with a Defect in Electron Transport at Complex III in Skeletal Muscle". Proceedings of the National Academy of Sciences. 81 (11): 3529. doi:10.1073/pnas.81.11.3529. PMC 345542.