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Palian was born on January 31 in Long Island, New York where she spent most of her life in NYC. The youngest of seven children from an Irish-Italian family, Regina became the first in her family to have a career in the arts. She knew at a young age that she wanted to act but decided to study and travel to broaden her horizons first.
Regina graduated St. John's University with a B.A. in English Literature and Art History from the American University of Rome. After finishing her degree Regina returned to the states to act on Stage, Film and TV Her major acting debut came in the 1995 off-off Broadway production of Timothy Leary in Space, where she was critically acclaimed as delightful. Some of her most recent film credit highlights include Mascara Di'Ablo, Fair Trade, Enigma and The Angels of Death. Her TV credits include CSI: Crime Scene Investigation (2008) and Boston Legal (2008). Her most recent stage credits include Macbeth, The Body & Soul of a Chinese Women, Savage in Limbo and Vampires. She currently lives in Los Angeles.
- O'Connor, Sheelagh (April 10, 2006). "THE BODY AND SOUL OF A CHINESE WOMAN by Sheelagh O'Connor". Eye Spy LA. Retrieved 23 May 2011.
- "Regina Palian resume". Actors Access. Retrieved 2012-01-02.