Region 1 or Region I can refer to:
- Region 1, a DVD region code
- Region 1, Northwest Territories
- Region 1, one of the health regions of Canada managed by Horizon Health Network
- Former Region 1 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006
- Region 1, an administrative region in Iran
- Tarapacá Region, Chile
- Ilocos Region, Philippines
|This disambiguation page lists articles associated with the title Region 1.
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