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Region 4 or Region IV can refer to:
- One of DVD region
- Region 4, Northwest Territories
- One of health regions of Canada managed by Vitalité Health Network
- Former Region 4 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006
- One of Regions of Iran
- Coquimbo Region, Chile
- Southern Tagalog, Philippines
- Illinois N4C Conference, a conference of the National Junior College Athletic Association, U.S.
- Calabarzon, Philippines
- Region 4, East Timor
| disambiguation page lists articles associated with the title Region 4.
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