Relapsing fever is a vector-borne disease caused by infection with certain bacteria in the genus Borrelia, which are transmitted through the bites of lice or soft-bodied ticks (genus Ornithodoros).
Signs and symptoms
Most people who are infected develop sickness between five and 15 days after they are bitten. The symptoms may include a sudden fever, chills, headaches, muscle or joint aches, and nausea. A rash may also occur. These symptoms usually continue for two to 9 days, then disappear. This cycle may continue for several weeks if the person is not treated.
Louse-borne relapsing fever
Along with Rickettsia prowazekii and Bartonella quintana, Borrelia recurrentis is one of three pathogens of which the body louse (Pediculus humanus humanus) is a vector. Louse-borne relapsing fever is more severe than the tick-borne variety.
Lice that feed on infected humans acquire the Borrelia organisms that then multiply in the gut of the louse. When an infected louse feeds on an uninfected human, the organism gains access when the victim crushes the louse or scratches the area where the louse is feeding. B. recurrentis infects the person via mucous membranes and then invades the bloodstream. No non-human, animal reservoir exists.
Tick-borne relapsing fever
Tick-borne relapsing fever is found primarily in Africa, Spain, Saudi Arabia, Asia, and certain areas of Canada and the western United States. Other relapsing infections are acquired from other Borrelia species, which can be spread from rodents, and serve as a reservoir for the infection, by a tick vector.
- Borrelia crocidurae – occurs in Egypt, Mali, Senegal, Tunisia; vectors – Ornithodoros erraticus, Ornithodoros sonrai; animal host – shrew (Crocidura stampflii)
- Borrelia duttoni, transmitted by the soft-bodied African tick Ornithodoros moubata, is responsible for the relapsing fever found in central, eastern, and southern Africa.
- Borrelia hermsii
- Borrelia hispanica
- Borrelia miyamotoi 
- Borrelia parkeri
- Borrelia turicatae
B. hermsii and B. recurrentis cause very similar diseases. However, one or two relapses are common with the disease associated with B. hermsii, which is also the most common cause of relapsing disease in the United States. (Three or four relapses are common with the disease caused by B. recurrentis, which has longer febrile and afebrile intervals and a longer incubation period than B. hermsii.)
Relapsing fever is a candidate etiology for a mysterious series of plagues in late-Medieval and early-Renaissance England. At the time, they were called sweating sicknesses. They have not recurred in epidemic form since the 16th century.
The diagnosis of relapsing fever can be made on blood smear as evidenced by the presence of spirochetes. Other spirochete illnesses (Lyme disease, syphilis, leptospirosis) do not show spirochetes on blood smear.
Relapsing fever is easily treated with a one- to two-week-course of antibiotics, and most people improve within 24 hours. Complications and death due to relapsing fever are rare.
Tetracycline-class antibiotics are most effective. These can, however, induce a Jarisch–Herxheimer reaction in over half those treated, producing anxiety, diaphoresis, fever, tachycardia and tachypnea with an initial pressor response followed rapidly by hypotension. Recent studies have shown tumor necrosis factor-alpha may be partly responsible for this reaction.
Currently, no vaccine against relapsing fever is available, but research is on-going. Developing a vaccine is very difficult because the spirochetes avoid the immune response of the infected person (or animal) through antigenic variation. Essentially, the pathogen stays one step ahead of antibodies by changing its surface proteins. These surface proteins, lipoproteins called variable major proteins, have only 30–70% of their amino acid sequences in common, which is sufficient to create a new antigenic "identity" for the organism. Antibodies in the blood that are binding to and clearing spirochetes expressing the old proteins do not recognize spirochetes expressing the new ones. Antigenic variation is common among pathogenic organisms. These include the agents of malaria, gonorrhea, and sleeping sickness. Important questions about antigenic variation are also relevant for such research areas as developing a vaccine against HIV and predicting the next influenza pandemic.
The physician David Livingstone is credited with the first account in 1857 of a malady associated with the bite of soft ticks in Angola and Mozambique. In 1904 and 1905, a series of papers outlined the cause of relapsing fever and its relationship with ticks. Both Joseph Everett Dutton and John Lancelot Todd contracted relapsing fever by performing autopsies while working in the eastern region of the Congo Free State. Dutton died there on February 27, 1905. The cause of tick-borne relapsing fever across central Africa was named Spirillum duttoni. In 1984, it was renamed Borrelia duttoni.
Sir William MacArthur suggested that relapsing fever was the cause of the yellow plague, variously called pestis flava, pestis ictericia, buidhe chonaill, or cron chonnaill, which struck early Medieval Britain and Ireland, and of epidemics which struck modern Ireland in the famine.
- Schwan T (1996). "Ticks and Borrelia: model systems for investigating pathogen-arthropod interactions". Infect Agents Dis 5 (3): 167–81. PMID 8805079.
- Schwan T, Piesman J; Piesman (2002). "Vector interactions and molecular adaptations of Lyme disease and relapsing fever spirochetes associated with transmission by ticks". Emerg Infect Dis 8 (2): 115–21. doi:10.3201/eid0802.010198. PMC 2732444. PMID 11897061.
- Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 432–4. ISBN 0-8385-8529-9.
- Fournier, Pierre-Edouard. "Human Pathogens in Body and Head Lice". Retrieved October 17, 2010.
- Cutler S (2006). "Possibilities for relapsing fever reemergence". Emerg Infect Dis 12 (3): 369–74. doi:10.3201/eid1205.050899 (inactive 2015-02-01). PMC 3291445. PMID 16704771.
- McNeil, Donald (19 September 2011). "New Tick-Borne Disease Is Discovered". The New York Times. pp. D6. Retrieved 20 September 2011.
- Livingstone D (1857) Missionary travels and researches in South Africa. London: John Murray
- Cook AR (1904). "Relapsing fever in Uganda". J Trop Med Hyg 7: 24–26.
- Ross, P. H.; Milne, A. D. (1904). ""Tick Fever."". British medical journal 2 (2291): 1453–4. PMC 2355890. PMID 20761784.
- Dutton JE, Todd JL (1905). "The nature of human tick-fever in the eastern part of the Congo Free State with notes on the distribution and bionomics of the tick". Liverpool School Trop Med Mem 17: 1–18.
- Wellman FC (1905). "Case of relapsing fever, with remarks on its occurrence in the tropics and its relation to "tick fever"". J Trop Med 8: 97–99.
- Novy, F. G.; Knapp, R. E. (1906). "Studies on Spirillum obermeieri and related organisms". Journal of Infectious Diseases 3 (3): 291. doi:10.1093/infdis/3.3.291. JSTOR 30071844.
- Kelly RT (1984) "Genus IV. Borrelia Swellengrebel 1907" in Krieg NR (ed.) Bergey's Manual of Systematic Bacteriology. Baltimore: Williams & Wilkins
- Bonser, Wilfrid and MacArthur, Sir Wm (1944). "Epidemics during the Anglo-Saxon period, with appendix: Famine fevers in England and Ireland". Journal of the British Archaeological Association 9: 48–71.
- MacArthur, W (1947). "Famine fevers in England and Ireland". Postgraduate medical journal 23 (260): 283–6. PMC 2529527. PMID 20248471.