Relaxin/insulin-like family peptide receptor 2

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Relaxin/insulin-like family peptide receptor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RXFP2 ; GPR106; GREAT; INSL3R; LGR8; LGR8.1; RXFPR2
External IDs OMIM606655 MGI2153463 HomoloGene15402 IUPHAR: 352 ChEMBL: 1628482 GeneCards: RXFP2 Gene
Species Human Mouse
Entrez 122042 140498
Ensembl ENSG00000133105 ENSMUSG00000053368
UniProt Q8WXD0 Q91ZZ5
RefSeq (mRNA) NM_001166058 NM_001289564
RefSeq (protein) NP_001159530 NP_001276493
Location (UCSC) Chr 13:
31.74 – 31.8 Mb
Chr 5:
150.02 – 150.08 Mb
PubMed search [1] [2]

Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a human G-protein coupled receptor.[1]

The receptors for glycoprotein hormones such as follicle-stimulating hormone (FSH; see MIM 136530) and thyroid-stimulating hormone (TSH; see MIM 188540) are G protein-coupled, 7-transmembrane receptors (GPCRs) with large N-terminal extracellular domains. Leucine-rich repeat (LRR)-containing GPCRs (LGRs) form a subgroup of the GPCR superfamily.[supplied by OMIM][1]

See also[edit]


External links[edit]

Further reading[edit]

  • Bathgate RA, Ivell R, Sanborn BM et al. (2005). "Receptors for relaxin family peptides". Ann. N. Y. Acad. Sci. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688. 
  • Bathgate RA, Ivell R, Sanborn BM et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. 
  • Hsu SY, Nakabayashi K, Nishi S et al. (2002). "Activation of orphan receptors by the hormone relaxin". Science 295 (5555): 671–4. doi:10.1126/science.1065654. PMID 11809971. 
  • Kumagai J, Hsu SY, Matsumi H et al. (2002). "INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent". J. Biol. Chem. 277 (35): 31283–6. doi:10.1074/jbc.C200398200. PMID 12114498. 
  • Gorlov IP, Kamat A, Bogatcheva NV et al. (2003). "Mutations of the GREAT gene cause cryptorchidism". Hum. Mol. Genet. 11 (19): 2309–18. doi:10.1093/hmg/11.19.2309. PMID 12217959. 
  • Sudo S, Kumagai J, Nishi S et al. (2003). "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2". J. Biol. Chem. 278 (10): 7855–62. doi:10.1074/jbc.M212457200. PMID 12506116. 
  • Ferlin A, Simonato M, Bartoloni L et al. (2003). "The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism". J. Clin. Endocrinol. Metab. 88 (9): 4273–9. doi:10.1210/jc.2003-030359. PMID 12970298. 
  • Roh J, Virtanen H, Kumagai J et al. (2004). "Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism". Reprod. Biomed. Online 7 (4): 400–6. doi:10.1016/S1472-6483(10)61883-4. PMID 14656401. 
  • Vinci G, Anjot MN, Trivin C et al. (2005). "An analysis of the genetic factors involved in testicular descent in a cohort of 14 male patients with anorchia". J. Clin. Endocrinol. Metab. 89 (12): 6282–5. doi:10.1210/jc.2004-0891. PMID 15579790. 
  • Büllesbach EE, Schwabe C (2005). "LGR8 signal activation by the relaxin-like factor". J. Biol. Chem. 280 (15): 14586–90. doi:10.1074/jbc.M414443200. PMID 15708846. 
  • Muda M, He C, Martini PG et al. (2005). "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity". Mol. Hum. Reprod. 11 (8): 591–600. doi:10.1093/molehr/gah205. PMID 16051677. 
  • Rosengren KJ, Zhang S, Lin F et al. (2006). "Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3". J. Biol. Chem. 281 (38): 28287–95. doi:10.1074/jbc.M603829200. PMID 16867980. 
  • Bogatcheva NV, Ferlin A, Feng S et al. (2007). "T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane". Am. J. Physiol. Endocrinol. Metab. 292 (1): E138–44. doi:10.1152/ajpendo.00228.2006. PMID 16926383. 
  • Scott DJ, Layfield S, Yan Y et al. (2007). "Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules". J. Biol. Chem. 281 (46): 34942–54. doi:10.1074/jbc.M602728200. PMID 16963451. 
  • El Houate B, Rouba H, Sibai H et al. (2007). "Novel mutations involving the INSL3 gene associated with cryptorchidism". J. Urol. 177 (5): 1947–51. doi:10.1016/j.juro.2007.01.002. PMID 17437853. 
  • Scott DJ, Wilkinson TN, Zhang S et al. (2007). "Defining the LGR8 residues involved in binding insulin-like peptide 3". Mol. Endocrinol. 21 (7): 1699–712. doi:10.1210/me.2007-0097. PMID 17473281. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.