Remdesivir

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Remdesivir
GS-5734 structure.png
Clinical data
SynonymsGS-5734
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
KEGG
Chemical and physical data
FormulaC27H35N6O8P
Molar mass602.585 g·mol−1
3D model (JSmol)

Remdesivir (development code GS-5734) is an antiviral drug, a novel nucleotide analog prodrug. It was developed by Gilead Sciences as a treatment for Ebola virus disease and Marburg virus infections, though it has subsequently also been found to show reasonable antiviral activity against more distantly related viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, and MERS-coronavirus.[1] Remdesivir was rapidly pushed through clinical trials due to the 2013–2016 West African Ebola virus epidemic crisis, eventually being used in at least one human patient despite its early development stage at the time. Preliminary results were promising and it was used in the emergency setting for the 2018 Kivu Ebola outbreak along with further clinical trials, until August 2019, when Congolese health officials announced it was ineffective compared to other treatments such as mAb114 and the Regeneron-produced REGN3470-3471-3479.[2][3][4][5][6][7][8] It may also help protect against Nipah and Hendra virus infections.[9][10]

See also[edit]

References[edit]

  1. ^ Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. mBio, 2018; 9 (2): e00221-18 Agostini, Maria L; Andres, Erica L; Sims, Amy C; Graham, Rachel L; Sheahan, Timothy P; Lu, Xiaotao; Smith, Everett Clinton; Case, James Brett; Feng, Joy Y; Jordan, Robert; Ray, Adrian S; Cihlar, Tomas; Siegel, Dustin; MacKman, Richard L; Clarke, Michael O; Baric, Ralph S; Denison, Mark R (2018). "Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease". mBio. 9 (2). doi:10.1128/mBio.00221-18. PMC 5844999. PMID 29511076.
  2. ^ Investigators also found that the drug was effective against SARS in mice, according to the study in the June 28 issue of the journal Science Translational Medicine. https://medlineplus.gov/news/fullstory_166953.html Tomas Cihlar, Gilead Sciences. Discovery and Development of GS-5734, a Novel Nucleotide Prodrug with Broad Spectrum Anti-Filovirus Activity. FANG-WHO Workshop, Fort Detrick, MD. 20 October 2015
  3. ^ Warren, Travis; Jordan, Robert; Lo, Michale; Soloveva, Veronica; Ray, Adrian; Bannister, Roy; MacKman, Richard; Perron, Michel; Stray, Kirsten; Feng, Joy; Xu, Yili; Wells, Jay; Stuthman, Kelly; Welch, Lisa; Doerffler, Edward; Zhang, Lijun; Chun, Kwon; Hui, Hon; Neville, Sean; Lew, Willard; Park, Yeojin; Babusis, Darius; Strickley, Robert; Wong, Pamela; Swaminathan, Swami; Lee, William; Mayers, Douglas; Cihlar, Tomas; Bavari, Sina (Fall 2015). "Nucleotide Prodrug GS-5734 Is a Broad-Spectrum Filovirus Inhibitor That Provides Complete Therapeutic Protection Against the Development of Ebola Virus Disease (EVD) in Infected Non-human Primates". Open Forum Infect Dis. 2. doi:10.1093/ofid/ofv130.02.
  4. ^ Warren, T. K.; Jordan, R; Lo, M. K.; Ray, A. S.; MacKman, R. L.; Soloveva, V; Siegel, D; Perron, M; Bannister, R; Hui, H. C.; Larson, N; Strickley, R; Wells, J; Stuthman, K. S.; Van Tongeren, S. A.; Garza, N. L.; Donnelly, G; Shurtleff, A. C.; Retterer, C. J.; Gharaibeh, D; Zamani, R; Kenny, T; Eaton, B. P.; Grimes, E; Welch, L. S.; Gomba, L; Wilhelmsen, C. L.; Nichols, D. K.; Nuss, J. E.; et al. (2016). "Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys". Nature. 531 (7594): 381–5. Bibcode:2016Natur.531..381W. doi:10.1038/nature17180. PMC 5551389. PMID 26934220.
  5. ^ Jacobs, M; Rodger, A; Bell, D. J.; Bhagani, S; Cropley, I; Filipe, A; Gifford, R. J.; Hopkins, S; Hughes, J; Jabeen, F; Johannessen, I; Karageorgopoulos, D; Lackenby, A; Lester, R; Liu, R. S.; MacConnachie, A; Mahungu, T; Martin, D; Marshall, N; Mepham, S; Orton, R; Palmarini, M; Patel, M; Perry, C; Peters, S. E.; Porter, D; Ritchie, D; Ritchie, N. D.; Seaton, R. A.; et al. (2016). "Late Ebola virus relapse causing meningoencephalitis: a case report". Lancet. 388 (10043): 498–503. doi:10.1016/S0140-6736(16)30386-5. PMC 4967715. PMID 27209148.
  6. ^ "Ebola Treatment Trials Launched In Democratic Republic Of The Congo Amid Outbreak". NPR.org. Retrieved 2019-05-28.
  7. ^ McNeil, Jr., Donald G. (12 August 2019). "A Cure for Ebola? Two New Treatments Prove Highly Effective in Congo". The New York Times. Retrieved 13 August 2019.
  8. ^ Molteni, Megan (12 August 2019). "Ebola is Now Curable. Here's How The New Treatments Work". Wired. Retrieved 13 August 2019.
  9. ^ "Experimental Ebola drug 'remdesivir' may help protect against Nipah virus, say scientists". 3 June 2019.
  10. ^ "Scientists Claim Drug Designed to Beat Ebola Also Fights Off Nipah". 2 June 2019.