Renal oncocytoma

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Renal oncocytoma
Renal oncocytoma3.jpg
Micrograph of a renal oncocytoma.

A renal oncocytoma is a tumour of the kidney made up of oncocytes, a special kind of cell.[1][2]

Signs and symptoms[edit]

Renal oncocytoma of the right kidney at CT.

Renal oncocytomas are often asymptomatic and are frequently discovered by chance on a CT or ultrasound of the abdomen. Possible signs and symptoms of a renal oncocytoma include blood in the urine, flank pain, and an abdominal mass.


Renal oncocytoma is thought to arise from the intercalated cells of collecting ducts of the kidney. It represent 5% to 15% of surgically resected renal neoplasms. Ultrastructurally, the eosinophilic cells have numerous mitochondria.

Histologic appearance[edit]

An oncocytoma is an epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing nuclei with large nucleoli with excessive amounts of mitochondria.


Gross appearance of a renal oncocytoma (left of image) and a slice of a normal kidney (right of image). Note the rounded contour, the mahogany colour and the central scar.

In gross appearance, the tumors are tan or mahogany brown, well circumscribed and contain a central scar. They may achieve a large size (up to 12 cm in diameter).

The main differential diagnosis of renal oncocytoma is chromophobe renal cell carcinoma oncocytic variant, which like the renal oncocytoma has eosinophilic cytoplasm, but has perinuclear clearing and, typically, some degree of nuclear atypia.

Immunohistochemical profile[edit]



Renal oncocytoma is considered benign, cured by nephrectomy. There are some familial cases in which these tumors are multicentric rather than solitary.[4] However, they may be resected to exclude a malignant tumor, e.g. renal cell carcinoma.

Additional images[edit]

See also[edit]


  1. ^ Coburn V, Radfar A, Snook D, Mahalingam M (2007). "Cutaneous oncocytoma - a report of three cases and review of the literature". J. Cutan. Pathol. 34 (4): 355–9. doi:10.1111/j.1600-0560.2006.00620.x. PMID 17381809.
  2. ^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology - Thyroid:oncocytic tumors". Retrieved 2009-02-01.
  3. ^ [Renal Neoplasms: An Update on Immunohistochemical and Histochemical Features]
  4. ^ Robbins pathology, page 1015[full citation needed]

External links[edit]