Replicative transposition

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Replicative transposition is a mechanism of transposition in molecular biology, proposed by James A. Shapiro in 1979,[1] in which the transposable element is duplicated during the reaction, so that the transposing entity is a copy of the original element. In this mechanism, the donor and receptor DNA sequences form a characteristic intermediate "theta" configuration, sometimes called a "Shapiro intermediate".[2] Replicative transposition is characteristic to retrotransposons and occurs from time to time in class II transposons.[3]


  1. ^ Shapiro, J. A. (1979), "Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements" (PDF), Proceedings of the National Academy of Sciences of the United States of America, 76 (4): 1933–1937, doi:10.1073/pnas.76.4.1933, PMC 383507Freely accessible, PMID 287033 .
  2. ^ Bushman, Frederic (2002), Lateral DNA transfer: mechanisms and consequences, CSHL Press, p. 46, ISBN 978-0-87969-621-4 .
  3. ^ Chaconas, George; Harshey, Rasika M. (2002), "Transposition of phage Mu DNA", in Craig, N. L.; Craigie, R.; Gellert, M.; Lambowitz, A. M., Mobile DNA II, American Society for Microbiology, pp. 384–402 .