Reptilase, an enzyme found in the venom of Bothrops snakes, has activity similar to thrombin. Unlike thrombin, reptilase is resistant to inhibition by antithrombin III. Thus, the reptilase time is not prolonged in blood samples containing heparin, hirudin, or direct thrombin inhibitors, whereas the thrombin time will be prolonged in these samples. Reptilase also differs from thrombin by releasing fibrinopeptide A, but not fibrinopeptide B, in its cleavage of fibrinogen.
Other causes of prolonged reptilase time include the presence of fibrin degradation products, which interfere with fibrin polymerization.
- Van Cott EM, Smith EY, Galanakis DK (August 2002). "Elevated fibrinogen in an acute phase reaction prolongs the reptilase time but typically not the thrombin time". Am. J. Clin. Pathol. 118 (2): 263–8. PMID 12162688. doi:10.1309/WUB3-72JT-E50M-EU8J.
- Johnson PJ, White Y, Woolf IL, Williams R (October 1977). "Reptilase time in cirrhosis and hepatocellular carcinoma". Br Med J. 2 (6091): 869–70. PMC . PMID 200301. doi:10.1136/bmj.2.6091.869-a.
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