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Resaena was the ancient name of the city of Ras al-Ayn, Syria.

Resaena was close to the frontier between the Roman Empire and the Sassanid Empire, and saw the alternate domination of the two powers between the 2nd and 4th century.

During the 3rd century it was basecamp of the III Parthica Roman legion. In 243, the Battle of Resaena saw the victory of a Roman army against its Sassanid counterpart.