Rescinnamine

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Rescinnamine
Rescinnamine.svg
Systematic (IUPAC) name
methyl (3β,16β,17α,18β,20α)-11,17-dimethoxy-18-{[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}yohimban-16-carboxylate
Clinical data
Legal status
  • (Prescription only)
Routes of
administration
oral
Identifiers
CAS Registry Number 24815-24-5 YesY
ATC code C02AA01
PubChem CID: 5280954
IUPHAR/BPS 7098
DrugBank DB01180 YesY
ChemSpider 4444446 YesY
UNII Q6W1F7DJ2D YesY
KEGG D00198 YesY
ChEBI CHEBI:28572 YesY
ChEMBL CHEMBL1668 YesY
Synonyms methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-{[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4(9),5,7-tetraene-19-carboxylate
Chemical data
Formula C35H42N2O9
Molecular mass 634.716 g/mol
 YesY (what is this?)  (verify)

Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug.

It is an vinca alkaloid obtained from Rauwolfia serpentina[1] and other species of Rauwolfia.[2]

Brand names[edit]

Moderil, Cinnasil, Anaprel

References[edit]

  1. ^ FIFE R, MACLAURIN JC, WRIGHT JH (December 1960). "Rescinnamine in treatment of hypertension in hospital clinic and in general practice". British Medical Journal 2 (5216): 1848–50. doi:10.1136/bmj.2.5216.1848. PMC 2098607. PMID 13699407. 
  2. ^ Balsevich J, Constabel F, Kurz WG. (1982). "Alkaloids of Vinca major cv. Variegata.". Planta Med. 44 (2): 91–3. doi:10.1055/s-2007-971409. PMID 17402086.