Retinal G protein coupled receptor

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Retinal G protein coupled receptor
Symbols RGR ; RP44
External IDs OMIM600342 MGI1929473 HomoloGene37709 GeneCards: RGR Gene
RNA expression pattern
PBB GE RGR 207070 at tn.png
More reference expression data
Species Human Mouse
Entrez 5995 57811
Ensembl ENSG00000148604 ENSMUSG00000021804
UniProt P47804 Q9Z2B3
RefSeq (mRNA) NM_001012720 NM_001301692
RefSeq (protein) NP_001012738 NP_001288621
Location (UCSC) Chr 10:
84.25 – 84.26 Mb
Chr 14:
37.04 – 37.05 Mb
PubMed search [1] [2]

RPE-retinal G protein-coupled receptor is a protein that in humans is encoded by the RGR gene.[1][2]


Defects in this gene are a cause of retinitis pigmentosa. The gene is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein presumably acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal, similar to retinochrome in invertebrates. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.[2]


Retinal G protein coupled receptor has been shown to interact with KIAA1279.[3]


  1. ^ Chen XN, Korenberg JR, Jiang M, Shen D, Fong HK (Jun 1996). "Localization of the human RGR opsin gene to chromosome 10q23". Human Genetics 97 (6): 720–2. doi:10.1007/BF02346179. PMID 8641686. 
  2. ^ a b "Entrez Gene: RGR retinal G protein coupled receptor". 
  3. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.