Retinal dehydrogenase

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retinal dehydrogenase
4wb9.jpg
retinal dehydrogenase inhibited by Yb
Identifiers
EC number1.2.1.36
CAS number37250-99-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a retinal dehydrogenase (EC 1.2.1.36) is an enzyme that catalyzes the chemical reaction

retinal + NAD+ + H2O retinoic acid + NADH + H+

The 3 substrates of this enzyme are retinal, NAD+, and H2O, whereas its 3 products are retinoic acid, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is retinal:NAD+ oxidoreductase. This enzyme is also called cytosolic retinal dehydrogenase. This enzyme participates in retinol metabolism. FAD is a cofactor.

References[edit]

  • Moffa DJ, Lotspeich FJ, Krause RF (1970). "Preparation and properties of retinal-oxidizing enzyme from rat intestinal mucosa". J. Biol. Chem. 245 (2): 439–47. PMID 4312676.