Retinal isomerase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
retinal isomerase
Identifiers
EC number5.2.1.3
CAS number9023-76-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a retinal isomerase (EC 5.2.1.3) is an enzyme that catalyzes the isomerisation of trans Retinal in eye into 11-cis-retinal which is form suitable to bind with protein opsin.

all-trans-retinal 11-cis-retinal

Hence, this enzyme has one substrate, all-trans-retinal, and one product, 11-cis-retinal.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is all-trans-retinal 11-cis-trans-isomerase. Other names in common use include retinene isomerase, and retinoid isomerase. This enzyme participates in retinol metabolism.

References[edit]

  • HUBBARD R (1956). "Retinene isomerase". J. Gen. Physiol. 39 (6): 935–62. doi:10.1085/jgp.39.6.935. PMC 2147571. PMID 13346046.
  • Shichi H, Somers RL (1974). "Possible involvement of retinylidene phospholipid in photoisomerization of all-trans-retinal to 11-cis-retinal". J. Biol. Chem. 249 (20): 6570–7. PMID 4472816.