Retinal oxidase

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retinal oxidase
EC number
CAS number 9033-52-7
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a retinal oxidase (EC is an enzyme that catalyzes the chemical reaction

retinal + O2 + H2O retinoic acid + H2O2

The 3 substrates of this enzyme are retinal, O2, and H2O, whereas its two products are retinoic acid and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is retinal:oxygen oxidoreductase. This enzyme is also called retinene oxidase. This enzyme participates in retinol metabolism.


  • Mandal SK, Datta Chaudhuri B (1987). "Enzymic oxidation of vitamin A aldehyde to vitamin A acid by rat livers of experimental thyroid disorders". Indian. J. Exp. Biol. 25 (11): 796–7. PMID 3452601. 
  • Huang DY, Furukawa A, Ichikawa Y (1999). "Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli". Arch. Biochem. Biophys. 364 (2): 264–72. doi:10.1006/abbi.1999.1129. PMID 10190983.