The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirusE1A protein and SV40 Large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
^Fan, S; Yuan R; Ma Y X; Xiong J; Meng Q; Erdos M; Zhao J N; Goldberg I D; Pestell R G; Rosen E M (August 2001). "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene (England) 20 (35): 4827–41. doi:10.1038/sj.onc.1204666. ISSN0950-9232. PMID11521194.
^ abJoaquin, Manel; Bessa Maria; Saville Mark K; Watson Roger J (November 2002). "B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107". Oncogene (England) 21 (52): 7923–32. doi:10.1038/sj.onc.1206001. ISSN0950-9232. PMID12439743.
Faha B, Ewen ME, Tsai LH et al. (1992). "Interaction between human cyclin A and adenovirus E1A-associated p107 protein.". Science255 (5040): 87–90. doi:10.1126/science.1532458. PMID1532458.CS1 maint: Explicit use of et al. (link)
Ewen ME, Xing YG, Lawrence JB, Livingston DM (1991). "Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein.". Cell66 (6): 1155–64. doi:10.1016/0092-8674(91)90038-Z. PMID1833063.
Ginsberg D, Vairo G, Chittenden T et al. (1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107.". Genes Dev.8 (22): 2665–79. doi:10.1101/gad.8.22.2665. PMID7958924.CS1 maint: Explicit use of et al. (link)
Beijersbergen RL, Kerkhoven RM, Zhu L et al. (1994). "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.". Genes Dev.8 (22): 2680–90. doi:10.1101/gad.8.22.2680. PMID7958925.CS1 maint: Explicit use of et al. (link)
Zhu L, van den Heuvel S, Helin K et al. (1993). "Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.". Genes Dev.7 (7A): 1111–25. doi:10.1101/gad.7.7a.1111. PMID8319904.CS1 maint: Explicit use of et al. (link)
Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.". Nat. Genet.19 (4): 371–4. doi:10.1038/1258. PMID9697699.