RhoD

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RHOD
Protein RHOD PDB 2j1l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RHOD, ARHD, RHOHP1, RHOM, Rho, RhoD, ras homolog family member D
External IDs MGI: 108446 HomoloGene: 22409 GeneCards: 29984
RNA expression pattern
PBB GE RHOD 209885 at tn.png

PBB GE RHOD 31846 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014578
NM_001300886

NM_007485

RefSeq (protein)

NP_055393.1

NP_031511.1

Location (UCSC) Chr 11: 67.06 – 67.07 Mb Chr 19: 4.43 – 4.44 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[3] It is encoded by the gene RHOD.[4]

It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.[4]

Interactions[edit]

RhoD has been shown to interact with CNKSR1[5] and DIAPH2.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823. 
  4. ^ a b "Entrez Gene: RHOD ras homolog gene family, member D". 
  5. ^ Jaffe, Aron B; Aspenström Pontus; Hall Alan (Feb 2004). "Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways". Mol. Cell. Biol. United States. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. ISSN 0270-7306. PMC 344169free to read. PMID 14749388. 
  6. ^ Gasman, Stéphane; Kalaidzidis Yannis; Zerial Marino (Mar 2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase". Nat. Cell Biol. England. 5 (3): 195–204. doi:10.1038/ncb935. ISSN 1465-7392. PMID 12577064. 

Further reading[edit]