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"RHOH" redirects here. For the television series, see Real Husbands of Hollywood.
Aliases RHOH, ARHH, TTF, RhoH, ras homolog family member H
External IDs MGI: 1921984 HomoloGene: 3180 GeneCards: 399
RNA expression pattern
PBB GE RHOH 204951 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 4: 40.19 – 40.25 Mb Chr 5: 65.86 – 65.9 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RHOH.[2]


Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells.[2]


RhoH has been shown to interact with ARHGDIA.[3][4]


  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823. 
  2. ^ a b "Entrez Gene: RHOH ras homolog gene family, member H". 
  3. ^ Li, Xiaoyu; Bu Xia; Lu Binfeng; Avraham Hava; Flavell Richard A; Lim Bing (February 2002). "The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function". Mol. Cell. Biol. (United States) 22 (4): 1158–71. doi:10.1128/MCB.22.4.1158-1171.2002. ISSN 0270-7306. PMC 134637. PMID 11809807. 
  4. ^ Fauré, J; Dagher M C (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie (France) 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. ISSN 0300-9084. PMID 11368848. 

Further reading[edit]