Ribonuclease 4

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RNASE4
Protein RNASE4 PDB 1rnf.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RNASE4, RAB1, RNS4, Ribonuclease 4, ribonuclease A family member 4
External IDs MGI: 1926217 HomoloGene: 10576 GeneCards: RNASE4
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_194431
NM_001282192
NM_001282193
NM_002937
NM_194430

NM_021472
NM_201239

RefSeq (protein)

NP_001269121
NP_001269122
NP_002928
NP_919412

n/a

Location (UCSC) Chr 14: 20.68 – 20.7 Mb Chr 14: 51.09 – 51.11 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ribonuclease 4 is an enzyme that in humans is encoded by the RNASE4 gene.[3][4]

The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.[4]

References[edit]

Further reading[edit]