Ribonucleoside-triphosphate reductase

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Ribonucleoside-triphosphate reductase
Identifiers
EC number 1.17.4.2
CAS number 9068-66-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Ribonucleoside-triphosphate reductase (EC 1.17.4.2, ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase) is an enzyme with system name 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O \rightleftharpoons ribonucleoside triphosphate + thioredoxin

Ribonucleoside-triphosphate reductase requires a cobamide coenzyme and ATP.

References[edit]

  1. ^ Blakley, R.L. (1965). "Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii". J. Biol. Chem. 240: 2173–2180. PMID 14299643. 
  2. ^ Goulian, M. and Beck, W.S. (1966). "Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii". J. Biol. Chem. 241: 4233–4242. PMID 5924645. 
  3. ^ Lammers, M. and Follmann, H. (1983). "The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation". Struct. Bonding 54: 27–91. doi:10.1007/bfb0111318. 

External links[edit]