Ribonucleoside-triphosphate reductase

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Ribonucleoside-triphosphate reductase
4coj.jpg
Ribonucleoside-triphosphate reductase dimer, Thermotoga maritima
Identifiers
EC number1.17.4.2
CAS number9068-66-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Ribonucleoside-triphosphate reductase (EC 1.17.4.2, ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase) is an enzyme with systematic name 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O ribonucleoside triphosphate + thioredoxin

Ribonucleoside-triphosphate reductase requires a cobamide coenzyme and ATP.

References[edit]

  1. ^ Blakley RL (May 1965). "Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii". The Journal of Biological Chemistry. 240: 2173–80. PMID 14299643.
  2. ^ Goulian M, Beck WS (September 1966). "Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii". The Journal of Biological Chemistry. 241 (18): 4233–42. PMID 5924645.
  3. ^ Lammers, M.; Follmann, H. (1983). "The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation". Struct. Bonding. 54: 27–91. doi:10.1007/bfb0111318.

External links[edit]