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Combination of
RifampicinRifamycin antibiotic
IsoniazidAnti-tuberculosis medication
PyrazinamideAnti-tuberculosis medication
Clinical data
Trade namesRifater, Trifazid, others
AHFS/Drugs.comFDA Professional Drug Information
  • C
Routes of
by mouth
ATC code
Legal status
Legal status
  • US: ℞-only
  • In general: ℞ (Prescription only)
PubChem CID
  • none

Rifampicin/isoniazid/pyrazinamide, also known as rifampin/isoniazid/pyrazinamide, is a medication used to treat tuberculosis.[1] It is a fixed dose combination of rifampicin, isoniazid, and pyrazinamide.[1] It is used either by itself or along with other antituberculosis medication.[1] It is taken by mouth.[1]

Side effects are those of the underlying medications.[1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness.[2] Severe side effects include liver problems.[3] Use in those under the age of 15 may not be appropriate.[3] It is unclear if use in pregnancy is safe for the baby.[3]

Rifampicin/isoniazid/pyrazinamide was approved for medical use in the United States in 1994.[3] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[4] The wholesale cost in the developing world is about 3.93 USD a month.[5] In the United Kingdom a month of treatment costs the NHS about 39.51 pounds.[6]

Medical uses[edit]

The purpose of the fixed dose combination is to make it easier for people to take their medication; but also to ensure that if people forget to take one or two of their drugs, they do not then develop resistance to the remaining drugs.

Society and culture[edit]

It is manufactured by Aventis.

See also[edit]


  1. ^ a b c d e WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 143. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
  2. ^ "Rifater Side Effects in Detail - Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
  3. ^ a b c d "Rifater - FDA prescribing information, side effects and uses". www.drugs.com. October 2016. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
  4. ^ "World Health Organization model list of essential medicines: 21st list 2019". 2019. hdl:10665/325771. Cite journal requires |journal= (help)
  5. ^ "Rifampicin + Isoniazid + Pyrazinamide". International Drug Price Indicator Guide. Retrieved 8 December 2016.
  6. ^ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 403. ISBN 9780857111562.