Ritanserin ( INN, USAN, BAN) is a serotonin receptor antagonist which was never marketed for clinical use but has been used in scientific research. 
Research [ edit ]
Ritanserin was tested in clinical trials for
schizophrenia and  migraine. 
Pharmacology [ edit ]
Ritanserin acts as a selective
5-HT (K 2A i = 0.45 nM) and 5-HT (K 2C receptor i = 0.71 nM) antagonist.  It has relatively low  affinity for the H, 1 D, 2 α, and 1-adrenergic α (39-, 77-, 107-, and 166-fold lower relative to 5-HT 2-adrenergic receptors 2A, respectively). The affinity of ritanserin for the  5-HT is than 1 µM. 1A receptor In addition to its affinity for the 5-HT  2A and 5-HT 2C receptors, ritanserin also binds to and antagonizes the 5-HT, 1D 5-HT, 2B 5-HT, 5A 5-HT, and 6 5-HT. 7 receptors 
atypical antipsychotic risperidone was developed from ritanserin. 
See also [ edit ]
References [ edit ]
^ Dr. Ian Morton; I.K. Morton; Judith M. Hall (31 October 1999). . Springer Science & Business Media. pp. 249–. Concise Dictionary of Pharmacological Agents: Properties and Synonyms ISBN 978-0-7514-0499-9.
^ a b Akhondzadeh S, Malek-Hosseini M, Ghoreishi A, Raznahan M, Rezazadeh SA (September 2008). "Effect of ritanserin, a 5HT2A/2C antagonist, on negative symptoms of schizophrenia: A double-blind randomized placebo-controlled study". Progress in neuro-psychopharmacology & biological psychiatry. 32 (8): 1879–83. PMID 18801405. doi: 10.1016/j.pnpbp.2008.08.020.
^ Nappi, G; Sandrini, G; Granella, F; Ruiz, L; Cerutti, G; Facchinetti, F; Blandini, F; Manzoni, GC (June 1990). "A new 5-HT2 antagonist (ritanserin) in the treatment of chronic headache with depression. A double-blind study vs amitriptyline.". Headache. 30 (7): 439–44. PMID 2119355. doi: 10.1111/j.1526-4610.1990.hed3007439.x.
^ a b c Leysen JE, Gommeren W, Van Gompel P, Wynants J, Janssen PF, Laduron PM (1985). "Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist.". Mol Pharmacol. 27 (6): 600–11. PMID 2860558.
^ . DIANE Publishing. 1 February 1993. pp. 361–. Harmful Non-Indigenous Species in the United States ISBN 978-0-7881-0441-1.
^ Bentham Science Publishers (May 1994). . Bentham Science Publishers. pp. 52–. Current Medicinal Chemistry