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Rho family GTPase 1
Protein RND1 PDB 2cls.png
PDB rendering based on 2cls.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RND1 ; ARHS; RHO6; RHOS
External IDs OMIM609038 MGI2444878 HomoloGene8706 GeneCards: RND1 Gene
RNA expression pattern
PBB GE RND1 210056 at tn.png
More reference expression data
Species Human Mouse
Entrez 27289 223881
Ensembl ENSG00000172602 ENSMUSG00000054855
UniProt Q92730 Q8BLR7
RefSeq (mRNA) NM_014470 NM_172612
RefSeq (protein) NP_055285 NP_766200
Location (UCSC) Chr 12:
48.86 – 48.87 Mb
Chr 15:
98.66 – 98.68 Mb
PubMed search [1] [2]

Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[1] It is encoded by the gene RND1.[2]

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][2]


Rnd1 has been shown to interact with GRB7,[3] PLXNB1,[4] PDE6D,[5][6] ARHGAP5[7] and UBXD5.[8]


  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823. 
  2. ^ a b "Entrez Gene: RND1 Rho family GTPase 1". 
  3. ^ Vayssière, B; Zalcman G; Mahé Y; Mirey G; Ligensa T; Weidner K M; Chardin P; Camonis J (February 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Lett. (NETHERLANDS) 467 (1): 91–6. doi:10.1016/S0014-5793(99)01530-6. ISSN 0014-5793. PMID 10664463. 
  4. ^ Oinuma, Izumi; Katoh Hironori; Harada Amane; Negishi Manabu (July 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. (United States) 278 (28): 25671–7. doi:10.1074/jbc.M303047200. ISSN 0021-9258. PMID 12730235. 
  5. ^ Nancy, Vanessa; Callebaut Isabelle; El Marjou Ahmed; de Gunzburg Jean (April 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. (United States) 277 (17): 15076–84. doi:10.1074/jbc.M109983200. ISSN 0021-9258. PMID 11786539. 
  6. ^ Hanzal-Bayer, Michael; Renault Louis; Roversi Pietro; Wittinghofer Alfred; Hillig Roman C (May 2002). "The complex of Arl2-GTP and PDEδ: from structure to function". EMBO J. (England) 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. ISSN 0261-4189. PMC 125981. PMID 11980706. 
  7. ^ Wennerberg, Krister; Forget Marie-Annick, Ellerbroek Shawn M, Arthur William T, Keith Burridge, Settleman Jeffrey, Der Channing J, Hansen Steen H (July 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. (England) 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. ISSN 0960-9822. PMID 12842009. 
  8. ^ Katoh, Hironori; Harada Amane; Mori Kazutoshi; Negishi Manabu (May 2002). "Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers". Mol. Cell. Biol. (United States) 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. ISSN 0270-7306. PMC 133765. PMID 11940653. 

Further reading[edit]