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Aliases RND2, ARHN, RHO7, RhoN, Rnd2, Rho family GTPase 2
External IDs MGI: 1338755 HomoloGene: 21123 GeneCards: RND2
RNA expression pattern
PBB GE RND2 213467 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 43.03 – 43.03 Mb Chr 11: 101.46 – 101.47 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Rnd2 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[3] It is encoded by the gene RND2.[4]


It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][5]

This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.

Clinical significance[edit]

The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.[4]


Rnd2 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ridley AJ (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823. 
  4. ^ a b "Entrez Gene: RND2 Rho family GTPase 2". 
  5. ^ "Entrez Gene: RND1 Rho family GTPase 1". 
  6. ^ Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. 13 (13): 1106–15. doi:10.1016/s0960-9822(03)00418-4. PMID 12842009. 
  7. ^ Naud N, Touré A, Liu J, Pineau C, Morin L, Dorseuil O, Escalier D, Chardin P, Gacon G (May 2003). "Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells". Biochem. J. 372 (Pt 1): 105–12. doi:10.1042/BJ20021652. PMC 1223378Freely accessible. PMID 12590651. 
  8. ^ Katoh H, Harada A, Mori K, Negishi M (May 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Mol. Cell. Biol. 22 (9): 2952–64. doi:10.1128/mcb.22.9.2952-2964.2002. PMC 133765Freely accessible. PMID 11940653. 

Further reading[edit]